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French researchers investigating the
association of genital human papillomavirus (HPV) with HIV acquisition searched
databases, including Medline, Embase, Web of Science, and the Cochrane database
and conference abstracts for studies published up to January 31, 2012. The
researchers focused on finding studies conducted with humans that reported data
on HIV incidence and determined the association of HIV with genital HPV
infection.
The researchers found 2,170 articles
and 431 conference proceedings. After removing duplicates and irrelevant
material, they were left with 14 abstracts, eight of which they rejected for
not meeting the inclusion criteria. They completed their final research with
five nested cohort studies and one case-control study on association between
genital HPV and HIV, with a total of 6,567 participants. Four studies focused
on female subjects and two on male. All studies, except one with men who have
sex with men, were conducted in sub-Saharan Africa with heterosexual adults;
two of the African studies were among high-risk women—mostly sex workers. The
researchers performed systematic review and meta-analysis on the studies as
well as subgroup analyses for high-risk and low-risk oncogenic (cancer-causing)
HPV risk groups.
All six studies reported significant
estimates of the association of HPV with HIV incidence. Results showed that
individuals with genital HPV infection, regardless of whether they were in a
high- or low-risk oncogenic risk group, had twice the risk of acquiring HIV.
The researchers suggested further research to determine the biological
mechanisms involved and to assess the effect of HPV vaccination on HIV
acquisition.
The Friends of AIDS Foundation is
dedicated to enhancing the quality of life for HIV positive individuals and
empowering people to make healthy choices to prevent the spread of the HIV
virus.
To learn more about The Friends of
AIDS Foundation, please visit: http://www.friendsofaids.org.
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